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Celebrex ® (Celecoxib) - Pharmacy Information and Drug Facts

Healthcare Information - brought to you by:
PHARMACIST WEEK
 

Patient Information Sheet
Celecoxib (marketed as Celebrex) - FDA APPROVAL DATE - 1998

This is a summary of the most important information about Celebrex. For details, talk to your healthcare provider.

FDA ALERT-[4/7/2005]: Celebrex has been linked to an increased risk of serious cardiovascular (CV) events (such as heart attack or stroke) which appears to be a risk shared by all medicines called non-steroidal anti-inflammatory drugs (NSAIDs) (excluding aspirin). FDA has requested that the package insert (labeling) for all NSAIDs, including Celebrex, be revised to include a “boxed” or serious warning to highlight the potential increased risk of CV events, and the well known risk of serious, and potentially life-threatening, stomach bleeding. FDA has also requested that the package insert for all NSAIDs be revised to state that patients who have just had heart surgery should not take these medicines.


What is Celebrex?

Celebrex is used to:

  • relieve symptoms of osteoarthritis (the arthritis caused by age-related “wear and tear” on bones and joints)
  • relieve symptoms of rheumatoid arthritis in adults
  • manage acute pain in adults (like the short term pain you can get after a dental or surgical operation)
  • treat painful menstrual cycles
  • reduce the number of colon and rectum growths (colorectal polyps) in patients with a disease called Familial Adenomatous Polyposis (FAP). FAP is an inherited disease in which the rectum and colon are covered with many polyps. Celebrex is used along with the usual care for FAP patients such as surgery and exams of the rectum and colon.

Who Should Not Take Celebrex?

Do not take Celebrex if you:

  • have had an allergic-type reaction to sulfa medicines.
  • have had asthma, hives or allergic-type reactions after taking aspirin or other NSAID (nonsteroidal anti-inflammatory drugs) medicines. If you have asthma, you may have aspirin-sensitive asthma. If an aspirin-sensitive asthmatic takes aspirin it can cause severe narrowing of the airway (bronchospasm), and even death. Since this type of reaction also has occurred after taking NSAIDs Celebrex should not be given to aspirin-sensitive patients.

Some examples of NSAIDs are ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve), diclofenac (Voltaren, Cataflam), and ketoprofen (Orudis). You can ask your doctor or pharmacist for a complete list of these medications.

  • are pregnant, especially during your last 3 months

What are The Risks?

Celebrex and other NSAID medicines can cause serious problems such as:

  • Stomach ulcers that bleed. The chance of this serious problem increases the longer you take Celebrex, but it can also happen suddenly. Stop taking Celebrex and call your healthcare professional right away if you get a burning stomach pain, black bowel movements that look like tar, or vomit that looks like blood or coffee grounds.
     
  • Liver damage. Some of the warning signs of liver damage are nausea, vomiting, tiredness, loss of appetite, itching, yellow coloring of skin or eyes, “flu-like” symptoms and dark urine. If this happens, stop taking Celebrex and call your healthcare professional right away.
     
  • Kidney problems that include sudden kidney failure or worsening of kidney problems that you already have.
     
  • Fluid retention (holding of water in your body) and swelling. Fluid retention can be a serious problem if you have high blood pressure or heart failure.

In addition to the serious side effects listed above, some common, but less serious side effects with Celebrex may include:

  • headache
  • indigestion
  • upper respiratory tract infection (a "cold")
  • diarrhea
  • sinus inflammation
  • stomach pain
  • nausea

What Should I Tell My Healthcare Professional?

Tell your healthcare professional if you:

  • have heart problems or high blood pressure
  • have liver or kidney problems
  • have or had stomach ulcers or stomach bleeding
  • have asthma
  • are allergic to aspirin or other NSAID medicines
  • are trying to become pregnant, are already pregnant, or are breast-feeding

Are There Any Interactions With Drugs or Foods?

Tell your healthcare professional about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how Celebrex works or Celebrex may affect how your other medicines work. Your healthcare professional may have to adjust your dose or watch you closely if you take any of the following medications:

  • certain blood pressure medicines called ACE inhibitors
  • furosemide
  • fluconazole or ketoconazole
  • phenytoin
  • warfarin
  • aspirin

SOURCE: FDA


 


CELEBREX DRUG NEWS

US doctors resume test of drug to fight lung cancer
Reuters AlertNet, UK
... a COX-2 inhibitor drug sold by Pfizer Inc. under the brand name Celebrex. The researchers suspended the trial last December at the ...
Latest research suggests using anti-inflammatories sparingly Kansas.com
Lung cancer chemoprevention trial with Celebrex Xagena.it

SHARP DECLINE SEEN IN TV DRUG ADVERTISING IN FIRST QUARTER OF 2005
Newsinferno.com, NY
... drug. Celebrex – Pfizer pulled all consumer ads in December 2004 after the well-publicized COX-2 cardiovascular problems surfaced. ...
Drugmakers cut back on television ad spending USA Today

Celebrex prescriptions plunge 40 percent
CNN 
NEW YORK (CNN/Money) - The health risks surrounding arthritis painkillers have caused physicians to back away from prescribing Celebrex, rather than propping ...

Safety first
Sarasota Herald-Tribune, FL 
... voluntarily suspended by its maker. A third drug, Celebrex, remains on the market but carries a consumer warning. Americans should be able ...

Chinese Medicine Alternatives to Health and Happiness
Bella Online
... After all the bad PR Vioxx and Celebrex received along with recent research findings on the uselessness of cough medicines (better off drinking hot chocolate ...

How to adopt anti-inflammatory way of living
Toledo Blade, OH 
... ways of relieving inflammation, most people would mention aspirin, Advil (ibuprofen), Aleve (naproxen), or prescription drugs like Vioxx, Bextra, and Celebrex. ...

Frist Wants 2-Year Wait on DTC Ads for New Drugs
DM News, NY
... advertising gained notoriety in the past year after the federal government asked drug companies to pull ads for drugs like Celebrex, Crestor, Levitra and Zyrtec ...

FDA looking into blindness as possible side effect of male ...
Foster's Daily Democrat, NH... Pfizer was asked to remove its pain reliever Bextra from the market because of its side effects and sales of its other arthritis drug Celebrex are falling. ...

Abortion Recall
Agape Press, MS
... You may be able to get Cash back!" The list of "cash cows" over the years is extensive: Accutane, Celebrex, Ephedra, Fen-Phen, Lamisil, Viagra, Vioxx ... ...

Painkiller health warning for kids
Australian, Australia 
A five-year study by researchers at the Royal Children's Hospital in Melbourne found Nurofen and Celebrex caused children to vomit blood, suffer acute kidney ...

NSAIDS effects place burdens upon the heart DRUG Q & A RICHARD ...
Wilkes Barre Times-Leader, PA ... The newer COX-2 NSAIDs include Celebrex, Vioxx, and Bextra. ... Soon, suspicions spread to Celebrex and Bextra, then to traditional NSAIDs. ...

New ways sought to cover drug costs
Oakland Press, MI
... more. Studies show that over-the-counter Ibuprofen can relieve pain just as well as Celebrex, a brand-name drug, Robbins said. "It's ...

Drug alerts induce reaction
Hilton Head Island Packet, SC
... When drugs such as Vioxx and Celebrex make the news, many patients taking those medicines tend to call their doctor or pharmacist to see what they should do.

Drug industry outperforms Merck, Pfizer
CNN 
... Drug Administration asked Pfizer to recall Bextra, a $1.3 billion drug, and said it was considering a black box, its most serious warning, for Celebrex, a $3.3 ...

Mass Medicating: The debate over prescription drug ads is growing
Santa Fe New Mexican, NM 
... Celebrex, which came under scrutiny by the FDA and is being marketed now with stronger warning labels, was a close second in its promotional budget. ...

A Drug Dispenser: Pfizer executive back in NC with free drugs for ...
Winston-Salem Journal, NC
... Rural Hall. Now in New York, he heads the Pfizer division that introduced the popular drugs Lipitor, Viagra and Celebrex. He visited ...

Vioxx on trial
NorthJersey.com, NJ
... led to broader questions about the safety of pain treatments, in particular the new Cox-2 inhibitor class of painkillers that included Celebrex and Bextra as ...

Five stocks ready for a comeback
Asbury Park Press, NJ
... potency drug Viagra, the company has a diverse portfolio of drugs, including Lipitor (to lower cholesterol), Zoloft (an antidepressant), and Celebrex (for pain ...

More Studies Link Painkillers to Heart Problems
Forbes 
... HealthDay News) -- Scientists on both sides of the Atlantic continue to uncover troubling news about commonly used painkillers, including ibuprofen and Celebrex ...

AMA Refuses to Back a Ban on Drug Ads
Newsday, NY
... they had a good chance of succeeding this year because of recent concerns about the heart risks of arthritis drugs like Vioxx and Celebrex, and suspicions that ...

Research Anew Links NSAIDs to Increased Cardiovascular Risk
MedPage Today, NJ ... recurrent congestive heart failure among patients taking Vioxx (rofecoxib) or prescription NSAIDs than among patients using Celebrex (Celecoxib), researchers ...

Common Painkillers Raise Heart-Attack Risk, Study Indicates
Bloomberg
... Holding AG and Aleve by Leverkusen, Germany-based Bayer AG as well as Whitehouse Station, New Jersey-based Merck's Vioxx and Pfizer Inc.'s Bextra and Celebrex. ...

Most Painkillers Up Heart Attack Risk
FOX News 
... the wake of the largest study to date showing most nonsteroidal anti-inflammatory drugs (NSAIDs) -- including ibuprofen, naproxen, and Celebrex -- increase the ...

Ibuprofen linked to heart risk
ABC Online, Australia 
... have been using such non-steroidal inflammatories (NSAIDS) much more since since it was found that Cox-2 inhibitors, like Vioxx and Celebrex, were linked to an ...

 
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